Dexrol -12TM - Dextromehtorphan HBr Extended Release Oral Liquid formulation
Written by Administrator
Saturday, 29 January 2011 10:04
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Dexrol -12TM is generic version of product from USA and indicated for 12 hours relief for persistent dry / irritating cough in adults. Cheminnova Remedies Pvt. Ltd is a first innovator company in India and only second company globally to have this kind of State-of-the-Art technology in Extended Release Oral liquids.

We at CRPL have developed a Patent Non-Infringing Process and Filed Patents to safeguard our
Innovation and also working on many such innovative but cost effective products, in pipeline in the area of
Cough / Cold, Pain Management and Anti Allergics.

Dextromethorphan HBr 30mg/5ml Extended Release Suspension is different from all existing brands of

cough medicine available as the active Ingredient is " Extended Release", This feature Which allows the drug to suppress the cough reflux for a longer period of time unlike in the other existing dosage forms which has to be taken for 4 to 5 times a day. Currently, Dextromethorphan extended Release Suspension 30mg/5ml is available only in United States of America.

In India, the Cough syrup market is estimated at about Rs.1850Cr, with an average increase of 18% every Year.

POTENTIAL SUSPENSION (ER DXM OS) OVER OTHER CONVENTIONAL FORMULATIONS AS FOLLOWS:

Development of sustained release formulation of Dextromethorphan can minimize the dose related adverse effects, cost and ultimately the patient compliance throughout the day and night with two doses only.

1) ER DXM OS allows for sustained therapeutic blood levels of the drug which results in consistent clinical response in the patient.

2) ER DXM OS maintains prolonged and consistent rate of drug release unlike highly fluctuating blood concentrations of Dextromethorphan HBr in conventional formulations.

3) ER DXM OS reduces adverse side effects as compared to Conventional Cough Syrup.

4) ER DXM OS maintains optimum drug concentration in the blood for more than 12 hours which improves efficacy of treatment with less amount of drug.

5) Another advantage of ER DXM OS is patient convenience, which leads to better patient compliance.